Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations
JOURNAL OF EDUCATION AND SCIENCE,
2018, Volume 27, Issue 1, Pages 35-42
A simple, accurate, rapid and sensitive visible spectrophotometric method has been developed for the determination of tolnaftate in pure and pharmaceutical preparations. The method is based on the reaction of tolnaftate with potassium permanganate in alkaline medium to form a bluish green colored product with an absorption maximum at 610 nm. Beer’s law was obeyed in the range of 5-60 µg/25ml with a molar absorbitivity of 5.379×104 L.mol.-1.cm-1. The optimum conditions for all color development were described and the proposed method has been successfully applied for the determination of tolnaftate in pharmaceutical preparations. A statistical comparison of these results with those of official method using (t and F) values at 95% confidence level, The calculated t- and F- values did not exceed the theoretical values indicating that there was no significant differences between the precision of the proposed and official method. So that the proposed method can be used as a routine quality control for determination of tolnaftate in pure form and in pharmaceutical formulations.The common excipients and additives did not interfere in the proposed method.
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