This research included a study of some Biochemical variables of male rats Wister with Induced liver Cancer and a study of the effect of extracts of three parts Annona Muricata, including seeds, core, and leaves to study its effects on the disease. The animals were divided into eight groups: I Control group, II treated with TAA, III treated with extract Core, IV treated with extract Seed, V treated with extract Leave, VI treated With TAA with extract Core, VII treated with TAA and extract Seed and, VIII TAA with extract Leave. In this study, the measurement kit was used to measure the Total Protein, Alkaline phosphatase, Total bilirubin, Aspartate transaminase, Alanine transaminase, and Alpha-fetoprotein. Manual Methods used to estimate Glutathione, Malondialdehyde, and Paraoxonase. The results showed a significant increase in the tumor-infected rats of Malondialdehyde, Alkaline phosphatase, Total bilirubin, Aspartate transaminase, Alanine-transaminase, and Alpha-fetoprotein compared to the control group, while there was a significant decrease in rats which treated with TAA of Total protein, Glutathione, and Paraoxonase compared to the control group. The results show a significant decrease in the levels in tumor-affected animals and treated with extract seed for each Malondialdehyde, Alkaline phosphatase, Total bilirubin, Aspartate transaminase, Alanine transaminase, and Alpha-fetoprotein compared to the group of rats affected and treated with the extract Core, and leaves, The results also showed a significant increase in the affected rats which treated with extract seeds for the level of Total protein, Glutathione, and Paraoxonase compared to the group treated with Core, leaves.