Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent
JOURNAL OF EDUCATION AND SCIENCE,
2005, Volume 17, Issue 4, Pages 1-10
AbstractA spectrophotometric method is proposed for the determination of microgram amounts of paracetamol based on the reaction of hydrolytic product of paracetamol (p-aminophenol) with chlorochresol in the presence of dissolved atmospheric oxygen and sodium carbonate, The absorbance of the blue indophenol dye is measured at 630 nm and the molar absorptivity found to be 8,63xl03 l.mol"1 .cm"' and conforms to Beer's law obeyed over the range 0.1-8.0 Hg ml' .The method is successfully employed for assay of paracetamol in various pharmaceutical formulations and results have been compared well with those obtained by the official methods indicating that the proposed method can be applied successfully in the assay of pharmaceutical preparations for paracetamol.
- Article View: 114
- PDF Download: 122