الملخص

Insects have been considered the main source of very useful chemical compounds. Today, the insect's innate immunity is a subject of antibiotic alternatives by experimenting with their body extracts. After application of the "Sequential solvent polarity" method. The dry body extract of the Americana cockroach, Periplaneta americana was exhibited had variable growth inhibition between the tasted pathogenic bacteria, the methanol cold extract was more effective than with other (Hexane, Diethyl ether, Ethyl acetate, Methanol) solvents by inhibition zone diameters; (29.0, 22.0,24.0, 22.3) mm for (Staphylococcus aureus , Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) respectively. In comparison between the antibacterial of the methanol extracts of the cockroach and the paper wasp Polistes watti, extract of the P. americana in more active in the inhibition of all four tested bacteria as follows: (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) for (7.7, 18.3, 8.7, 6.0) mm respectively. Extract of P. americana have antibacterial activity do to it living in an ecological niche which characterized by organic and bacterial pollution so, the growth of human pathogenic bacteria in more inhibited than the social entomophagous  P. watti wasp. The present study had given promise alternative of the personal antibiotics, by as more effective than the standers drugs (Ceftriaxone, Gentamicin) after separation and identification of the active molecules and used as a template for the future manufacturing industry.