الملخص

ABSTRACT The synthesis of amino acid hydrazide derivatives (4a-f) has been achieved by condensation of the corresponding amino acid hydrazide [3] (which synthesized from sulfanilamide as starting material) with aldehydes or ketones. Compound [3] is also used as a synthone to obtain 1,3,4-oxadiazole-5-thiole [5], which upon reaction with alkyl halide and aldehyde gave compounds (6,7) and (9a-b) respectively. Compound [5] was also allowed to undergo Mannich reaction to give compounds (8a-b). The structure of the synthesized compounds has been confirmed by physical and spectral methods .