الملخص

Abstract This study was conducted to evaluate the effect of diet supplementation with zinc and copper on some biochemical parameters in rats and susceptability to induction of diabetes by alloxan, and there effect to delay diabetes induced by alloxan. Albino male rats divided randomly into several groups.group one served as control. Group two and three given diet contain 15, 25 mg zinc /kg diet respectively, group four and five recieved 1,3 mg copper /kg diet respectively, for two weeks of treatment. Other group induced diabetes and let without treatment and considered as a diabetic control group. Results Showed a significant decrease in both serum glucose and cholesterol levels in comparing with control group, with an a significant increase in levels of both malondialdehyde and glutathione, the results also showed that both zinc and copper treatment delayed the induction of diabetes by alloxan. We conclude from this work that both zinc and copper have important effect on studied parameters and on susceptability of diabetes induced by alloxan.