الملخص

This study was conducted to explore the effect of  cisplatin  on the kidney of  Swiss BALB/c mice through treatement with cisplatin at the concentrations (2mg/kg, 3mg/kg,4mg/kg) along30 days. Histopathological changes of the kidney at the concentration 2mg/kg elucidated swelling of renal tubules, vacuolation of interstitial tissue, collapse of some glomeruli, Degeneration and Haemorrhage of interstitial tissue. At the concentration 3mg/kg, thickinning of blood vessels, Hypertrophy of nuclus of endothelial cells, degeneration, vacuolation and Deterioration of renal tubules and Haemorrhage  of interstitial tissue. At the concentration 4mg/kg huge collapse in some glomeruli, swelling of some epithelial cell and Deterioration of renal tubules, appearance of some  phagocytic cells and pyknosis of the cytoplasm of most renal tubules, were observed. Keywords:  Cisplatin, Toxicity, Histopathology