Abstract: In this research, a number of chemical compounds were estimated and identified in the crude extract of both E. helioscopia and E. peplus species, as it was noted that there were about twenty alkaloid compounds in them, and It was, also, noted that there were three alkaloid compounds present in the extract of both E. helioscopia and E. peplus species. E. peplus had the highest concentration of the alkaloids: Scopalamine, Colchicino and theobromine. Presence of the following alkaloids was observed in the Species E. helioscopia, namely; Metamfepramone, Phencyclidine, Tramadol, Caffeoylquinic, Each of following alkaloids; Benzfetamine, Di phenhydramine, Theobromine, MethaquaIone, CoIchicine, Atropine QuinoIine, Thebaine, Iupinine, Scopaiamine, Catechin, Noscapine, , were found in the crude extract of the type Euphorbia peplus . Results of the high- performance liquid chromatography (HPLC) analysis showed changes in terms of their contents of phenolic compounds and their concentrations. Approximately 12 phenolic compounds were found, as the following compounds were found in Both types, but with different concentrations, including Pyrogallol, Gallic acid, Rutin, Kaempferol, Cinnamic, Catechol, Cinnamaldehyde, Qurctin, Eugnol, Lignan, Chlorogenic, 4-hydroxybenzoic.