Abstract
Abstract This study provides novel information on the role of castration and testosterone hormone replacement at (5ng/kg B. Wt.) in rats in the parameters each of red blood corpuscles count, hemoglobin concentration, packed cell volume (PCV), erythrocytes indexes, total leucocytes count, differential leucocytes count, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, alanine aminotransferase enzyme activity, total proteins, albumin, globulin, glucose and body weight parameters in rats. Castration of the rats caused a significant decrease in red blood corpuscles, hemoglobin concentration and packed cell volume; accompanied with significant increased mean corpuscular volume, mean corpuscular hemoglobin, total number of leucocytes, and percentage of neutrophils and low percentage of lymphocytes compared with control group. Treatment with testosterone hormone caused significant increased in red blood corpuscles, hemoglobin concentration and packed cells volume and significant decreased in total number of leucocytes, neutrophils and increased in the number of lymphocytes. The present study showed a significant increase in the levels of total cholesterol, triglycerides, low density lipoprotein in castrated rats group compared with control value. Administration of testosterone hormone caused significant decreased in the levels of total cholesterol, triglycerides, and low density lipoproteins compared with castrated rats group. The current study showed no significant differences between groups in mean corpuscular hemoglobin concentration, high density lipoproteins, total protein, albumin, globulin, glucose, alanine aminotrasferase enzyme activity and body weights .We concluded from this study that castration of the rats produced significant effects in certain blood constituent and lipid profile. Moreover administration of testosterone hormone reversed the adversed effects caused by castration.
